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However, paradoxical stimulation ranging from excitation through to tremors, hallucinations and convulsions may occur.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. We plan to examine whether patients who did not tolerate cetirizine due to sedation are able to tolerate levocetirizine. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis.

Listing a study does not mean it has been evaluated by the U. This study will utilize a randomized, double-blind, placebo controlled trial comparing levocetirizine, cetirizine, and placebo in regards to sedation and allergy symptom scores.

"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.

The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

"My advice is that you shouldn't make up your mind based exclusively on what you hear in advertising," says Bender, a psychologist who serves as an assembly chairman of the American Thoracic Society.

"The newer prescribed medications are very expensive, and until you try it, you don't really know whether an old-fashioned, 5- or 10-cent, first-generation capsule will take care of your symptoms without causing sedation." But others studies show a big difference -- including one trial conducted at the University of Iowa three years ago in which researchers gave patients simulated driving tests after administering either Allegra, Bendryl, a placebo, or enough alcohol to make the patient legally drunk.

Sedating antihistamines have the ability to cross the blood-brain barrier, the ability to bind to non-histamine receptors and have less selectivity for peripheral or central H1-receptors.

The most common adverse effects with sedating antihistamines are sedation, dizziness and incoordination.

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" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

"And based on that study, I certainly wouldn't have wanted to face those Benadryl people on the road." In Bender's analysis, some studies involved self-reported levels of sedation, while others measured their ability to perform specific tasks.